High Serum IgE Concentration in Patients with Psoriasis

Psoriasis is a common chronic skin disorder characterized by abnormal epidermal proliferation and infiltration of inflammatory cells which affects approximately 2-4 % of the general population [1-3]. Psoriasis Vulgaris (PV), the most common clinical variant, comprises 85 to 90% of all patients with psoriasis. This disease is usually manifested as well-demarcated erythematous oval plaques with silvery scale on extensor surfaces. Pustular psoriasis (PP) is an uncommon but potentially lifethreatened clinical variant that presents with multiple sterile pustules on erythematous background. Erythrodermic Psoriasis (PE) is a variant that may affect all body sites and involves less than 2% of all psoriatic patients. Psoriatic Arthritis (PsA) is characterized by pain, swelling and tenderness of the involved joints, which may lead to joint damage and disability in the end. Several studies have validated that psoriasis is associated with multiple comorbidities and greatly reduces the quality of patients’ life by impacting patients psychologically and physically [4,5]. However, the pathogenesis of psoriasis is complex and remains poorly understood [6].